Association of positive thyroid auto antibodies with thyroid carcinoma.
نویسندگان
چکیده
The association between thyroid autoimmunity and thyroid cancer was carried out in a series of solitary thyroid nodules submitted to fine-needle aspiration cytology and subsequent histopathology. US guided FNACs were obtained from 295 unselected consecutive patients with single thyroid nodules and positive (98) or negative (197) serum anti-thyroid antibody. Cytological results were classified in three classes of increased risk of malignancy: low risk (class II); indeterminate risk (class III); and suspect or malignant (class IV). A higher prevalence of class III (29.6%, p<0.05) and class IV (17.34%, p<0.05) and lower prevalence of class II (52.06%, p<0.01) were found in ATA+ nodules respectively. By multivariate logistic regression analysis ATA+ conferred a significant risk (odds ratio: 1.97 & 95% confidence interval: 0.97-3.97) for class IV cytology independently for age and sex. In 53 patients where thyroidectomy was carried out, thyroid cancer was found in (86.66%) patients with class IV nodules, in (19.4%) of class III nodules (all ATA-) and in none of 7 class II nodules. Histologically proven thyroid cancer (mostly papillary) was then observed in a higher proportion (13.2%) of ATA+, when compared with ATA- nodules (8.1%, p>0.01), but the significance of this finding is limited by the low number of class II nodules operated on. The presence of ATA+ confers an increased risk of suspicious or malignant cytology in solitary thyroid nodules.
منابع مشابه
ارتباط کهیر مزمن با اتوایمونیتی تیروئید
Background and Purpose: chronic urticaria is a tormenter and does not have a known etiology. Association between chronic urticaria and thyroid auto-immunity has shown different results. The aim of this study is to evaluate the effect of Levo-thyroxine on the chronic urticaria and association between chronic urticaria with thyroid auto-immunity. Materials and Methods: In a prospective case-...
متن کاملBackground: Thyroid antibodies have a key role in follow up of the patients with thyroid carcinoma, thus present study investigates thyroid antibodies in patients with differentiated thyroid carcinoma. Material and Methods: For this cross sectional study, 157 patients with differentiated thyroid carcinoma (case group) and 434 healthy subjects (control group) were included. Serum level of antit...
متن کاملآنتیبادیهای تیروئید در بیماران با سرطان دیفرانسیه تیروئید در تهران
Background: Thyroid antibodies have a key role in follow up of the patients with thyroid carcinoma, thus present study investigates thyroid antibodies in patients with differentiated thyroid carcinoma. Material and Methods: For this cross sectional study, 157 patients with differentiated thyroid carcinoma (case group) and 434 healthy subjects (control group) were included. Serum level of antit...
متن کاملThe Presence of Anti Thyroid and Anti Ovarian Auto-Antibodies in Familial Premature Ovarian Failure
Background Premature ovarian failure (POF) is a disorder of multi causal etiology. Autoimmunity has been proposed as a mechanism for some cases of ovarian follicle dysfunction which is evident in POF. The aim of this study was to identify the level of auto-antibodies in POF and familial POF patients. MaterialsAndMethods In this study, auto-antibodies including anti-ovarian antibody (AOA), anti ...
متن کاملPrevalence of Thyroid Autoantibodies in Type 2 Diabetic Patients
OBJECTIVE: Due to the increased prevalence of thyroid dysfunction in subjects with type 2 diabetes and also this fact that antibodies could potentially identify subjects at risk of thyroid dysfunction, this study was conducted to investigate thyroid autoimmunity in type 2 diabetic patients. MATERIAL AND METHODS: Among patients referred to Yazd Diabetes Research Center, 4000 type 2 diabetic pat...
متن کاملتعیین شیوع بیماری اتوایمیون تیرویید در بیماران با دیابت ملیتوس تیپ یک مراجعه کننده به بیمارستان های حضرت رسول و علی اصغر تهران طی سال های 1385 تا 1390
Background: Type 1 diabetes mellitus (T1DM) is a chronic autoimmune disease co-occurred with a high incidence of other autoimmune disorders including thyroid function abnormalities. This study investigated the prevalence of autoimmune thyroid disorders in patients with T1DM. Methods: In this retrospective cross sectional study, 150 patients with T1DM aged 7 - 17 years old, admitted in Al...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- Mymensingh medical journal : MMJ
دوره 21 4 شماره
صفحات -
تاریخ انتشار 2012